教育经历

1995-1999 武汉大学，学士

1999-2007 美国伊利诺大学香槟分校，博士

工作经历与任职

2007-2011 美国罗切斯特大学，博士后研究员

2011-2018 美国布兰迪斯大学，博士后研究员

2018-至今 武汉大学医学研究院，教授

获奖情况

2016 MDI Biological Laboratory差旅奖金

研究领域

主要从事神经信号传导方面的研究。系统阐述了哺乳动物中神经兴奋性的调控机制，以及神经信号受昼夜节律调控的机制。曾在温度感受神经信号传导方面做出了系统性、原创性的研究工作。发现了新的温度感受器家族；阐明了此温度感受器下游的信号传导通路；并从分子和神经回路的层面揭示了温度感受神经元可塑性的机理。为了解复杂的神经信号传导机制做出了贡献。

代表性论文

Takeishi1 A*, Yu YV*, Hapiak VM, Bell HW, O’Leary T, Sengupta P. Receptor-type guanylyl cyclases are thermosensory proteins in C. elegans. Neuron. (2016) 90:235

Yu YV*, Bell HW*, Glauser DA, Van Hooser SD, Goodman MB, Sengupta P. CaMKI-dependent regulation of sensory gene expression mediates experience-dependent plasticity in the operating range of a thermosensory neuron. Neuron. (2014) 84: 919

Schild LC, Zbinden L, Bell HW, Yu YV, Sengupta P, Goodman MB, Glauser DA. The balance between cytoplasmic and nuclear CaM kinase-1 signaling controls the operating range of noxious heat avoidance. Neuron. (2014) 84:983

Gaspar I*, Yu YV*, Cotton SL, Kim DH, Ephrussi A, Welte MA. Klar ensures thermal robustness of oskar localization by restraining RNP motility. J Cell Biol. (2014) 206:199

Jin YN, Yu YV, Gundemir S, Jo C, Cui M, Tieu K, Johnson GV.  Impaired mitochondrial dynamics and Nrf2 signaling contribute to compromised responses to oxidative stress in striatal cells expressing full-length mutant huntingtin. PLoS One. (2013) 8(3):e57932

Elhanany-Tamir H, Yu YV, Shnayder M, Jain A, Welte MA, Volk T. Organelle positioning in muscles requires cooperation between two KASH proteins and microtubules. J Cell Biol. (2012) 198:833

Wang TA*, Yu YV*, Govindaiah G, Ye X, Artinian L, Coleman TP, Sweedler JV, Cox CL, Gillette MU. Circadian rhythm of redox state regulates excitability in suprachiasmatic nucleus neurons. Science. (2012) 337:839

Yu YV, Li ZH, Rizzo NP, Einstein J, Welte MA. Targeting the Motor Regulator Klar to Lipid Droplets. BMC Cell Biol. (2011) 12:9

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