教育经历

2001.09-2005.07 上海交通大学植物生物技术专业，学士

2005.09-2011.07 北京大学生物技术，博士

2007.12-2009.12 日本国立农业研究中心，联合培养博士

工作经历与任职

2011.09-2015.03 北京大学BIOPIC，博士后 导师：谢晓亮教授

2012.03-2012.09 美国哈佛大学化学与化学生物系，博士后 导师：谢晓亮教授

2015.04-2018.12 北京大学BIOPIC，助理研究员

2019.02-     武汉大学，教授

研究领域

   主要从单细胞水平研究细菌耐药和宿主免疫反应机制。我们拟结合微流控技术运用生物动态光学成像技术从单细胞水平对耐药菌的形成、复苏和耐药的机制进一步深入的研究；并将利用单细胞测序技术探索持留菌与宿主免疫系统相互作用的关系，为耐药菌在临床中的预防和治疗奠定良好的理论基础。

代表性论文

1．Pu Y, Li Y, Bai F, et al. (2018). ATP-dependent dynamic protein aggregation regulates bacterial dormancy depth critical for antibiotic tolerance. Molecular Cell, Nov. 21, 2018, online.

2．Pu Y, Ke Y, Bai F. (2017). Active efflux in dormant bacterial cells - New insights into antibiotic persistence. Drug Resist Updat 30, 7-14.

3．Jin L, Qin Q, Wang Y, Pu Y, Li Y, et al. (2017). Rice Dwarf Virus P2 Protein Hijacks Auxin Signaling by Directly Targeting the Rice OsIAA10 Protein, Enhancing Viral Infection and Disease Development. PLoS Pathogens 12(9):e1005847.

4．Pu Y, Zhao Z, Li Y, Bai F, Xie X, et al. (2016). Enhanced Efflux Activity Facilitates Drug Tolerance in Dormant Bacterial Cells. Molecular Cell, 62, 284-294. (Highlighted by Nature https://www.nature.com/articles/nature18442 and Nature Review Microbiology https://www.nature.com/articles/nrmicro.2016.72)

5．Guo X, Jin X, Lv X, Pu Y, Bai F*. (2015) Real Time Visualization of Perylene Nano-clusters (PNCs) in Water and Their Partitioning to Graphene Surface and Macrophage Cells. Environmental Science & Technology, 49 (13): 7926-7933.

6．Liu Y, Yang J, Zhao Z, Pu Y*, Bai F*. (2014) Bacterial Persistence. Science China Chemistry, 57 (12): 1625-1633 (CORRESPONDANT AUTHOR)

7．Pu Y, Kikuchi A, Moriyasu Y, Tomara M, Jin Y, Suga H, Wei T, Li Y, Omura T. (2011) Rice dwarf viruses with dysfunctional genomes generated in plants are filtered out in vector insects -implications for the virus origin. Journal of Virology, 85 (6): 2975-2979.

8．Akita F, Higashiura A, Shimizi T, Pu Y, Suzuki M, Ichiki T, Sasaya T, Kanamaru S, Arisaka F, Tsukihara T, Nakagawa A, Omura T. (2012) Crystal Structure and Octamerization of the Viroplasm Matrix Protein P9-1 of Rice Black Streaked Dwarf Virus. Journal of Virology, 86 (2): 746-756.

9．Zhou F, Pu Y, Wei T, Liu H, Deng W, Wei CH, Ding B, Omura T, Li Y. (2007). The P2 capsid protein of the nonenveloped rice dwarf phytoreovirus induces membrane fusion in insect host cells. Proceedings of the National Academy of Sciences USA. 104(49): 19547-19552.

10．Zhou F, Wu G, Deng W, Pu Y, Wei C, Li Y. (2007). Interaction of rice dwarf virus outer capsid P8 protein with rice glycolate oxidase mediates relocalization of P8. Febs Letters 581(1): 34-40.

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