教育经历    

2002-2006   武汉大学生命科学学院  学士  

2007-2011   中国科学院生物物理研究所 博士  

工作经历与任职    

2011-2014   美国北卡罗莱纳大学教堂山分校 博士后  

2014-2018   美国北卡罗莱纳大学教堂山分校 研究助理  

2018-2020   美国北卡罗莱纳大学教堂山分校 研究助理教授  

2020-至今    武汉大学医学研究院/免疫与代谢前沿科学中心 教授  

获奖情况

2018 New Investigator Scholarship, Conference on Retroviruses and  Opportunistic Infections (CROI)，美国

2017 美国免疫学家学会“Abstract Award”，美国

2016 美国免疫学家学会“Abstract Award”，美国

2015 美国免疫学家学会“Abstract Award”，美国

2011 中国科学院地奥奖学金, 中国

学术兼职

2019 – 至今 Associate Editor, BMC immunology

研究领域

  实验室主要研究病毒感染的免疫致病机制及免疫治疗。我们利用独特的人源化小鼠模型，结合临床标本，运用免疫学、遗传学、单细胞转录组及代谢组学等手段，研究病毒感染导致机体炎症、免疫代谢紊乱、T细胞功能耗竭的调控机制，并致力于开发新的免疫治疗策略。同时，我们还研究肿瘤炎症微环境对免疫细胞表型及功能的调控作用，以挖掘肿瘤免疫治疗新靶点。

代表性论文（15 out of 28） 

1. L Cheng*, H Yu, J Wrobel, G Li, P Liu, Z Hu, X Xu, L Su. Identification of pathogenic TRAIL-expressing innate immune cells during HIV-1 infection in humanized mice by scRNA-Seq. JCI Insight. 5(11):e135344. (2020). *Co-corresponding author.

2. L Cheng, Q Wang, G Li, J Ma, H Yu, F Yasui, Z Zhang, S Zurawski, G Zurawski, Y Levy, L Su. TLR3 agonist/CD40-targeting vaccination induces T cell response and reduces HIV-1 reservoirs. The Journal of Clinical Investigation. 128(10):4387-4396. (2018).

3. L Cheng*, J Ma, G Li, L Su*. Humanized mice engrafted with human HSC only or HSC and thymus support comparable HIV-1 replication, immunopathology and responses to ART  and immune therapy. Frontiers in Immunology. Apr 19; 9:817. (2018).  *Co-corresponding author.

4. J Zhao^#, L Cheng^#, H Wang, H Yu, B Tu, Q Fu, G Li, Q Wang, Z Liu, L Zhang, L Su, Z Zhang. Infection and depletion of CD4+ group-1 innate lymphoid cells by HIV-1 via type-I interferon pathway. PLoS pathogens. Jan 5; 14(1): e1006819. (2018). ^#Equal contribution

5. L Cheng^#, J Ma^#, J Li^#, D Li, G Li, F Li, Q Zhang, H Yu, F Yasui, C Ye, L-C Tsao, Z  Hu, L Su, L Zhang. Blocking type I interferon signaling enhances T cell recovery and reduces HIV-1 reservoirs. The Journal of Clinical Investigation. 127(1), 269-279. (2017) (Editor’s Pick; Commentary by Steven G. Deeks et al., JCI, 127:103-105. Highlight in Editors'  Choice by Science Translational Medicine.)

6. L Cheng*, H Yu, G Li, F Li, J Ma, J Li, L Chi, L Zhang*, L Su*. Type I Interferons Suppress  Viral Replication but Contribute to T Cell Depletion and Dysfunction during Chronic HIV-1  Infection. JCI Insight. 2(12): e94366. (2017). *Co-corresponding author.

7. L Cheng, Z Zhang, G Li, F Li, L Wang, L Zhang, S Zurawski, G Zurawski, Y Levy, L Su. Human innate responses and adjuvant activity of TLR ligands in vivo in mice reconstituted with a human immune system. Vaccine. Sep 25. pii: S0264-410X (17)31300-2. (2017).

8. Z Zhang^#, L Cheng^#, J Zhao^#, G Li, L Zhang, W Chen, W Nie, N-J Reszka-Blanco, F-S Wang, L Su. Plasmacytoid dendritic cells promote HIV-1-induced group 3 innate lymphoid cell depletion. The Journal of Clinical Investigation. 125, 3692-3703. (2015). ^# Equal contribution. (Editor’s Pick; Commentary by Yang-Xin Fu et al., JCI, 125:3430-31.)

9. L Cheng, F Li, M Bility, C Murphy, and L Su. Modeling hepatitis B virus infection,  immunopathology and therapy in mice. Antiviral research. 121, 1-8. (2015).

10. L Cheng^#, X Du^#, Z Wang, J Ju, M Jia, Q Huang, Q Xing, M Xu, Y Tan, M Liu, P Du, L Su, S Wang. Hyper-IL-15 suppresses metastatic and autochthonous liver cancers by promoting tumor-specific CD8 T cell responses. Journal of Hepatology. 61, 1297-1303. (2014). ^# Equal contribution.

11. L. Cheng, J. Wang, X. Li, Q. Xing, P. Du, L. Su, S. Wang. Interleukin-6 induces Gr-1+CD11b+ myeloid cells to suppress CD8+ T cell-mediated liver injury in mice. PloS one. 6, e1763. (2011).

12. F. Li, L. Cheng, C. M. Murphy, N. J. Reszka-Blanco, Y. Wu, L. Chi, J. Hu, L. Su, Minicircle HBV cccDNA with a Gaussia luciferase reporter for investigating HBV cccDNA biology and developing cccDNA-targeting drugs. Sci Rep. 6, 36483. (2016).

13. M.T. Bility, L. Cheng, Z. Zhang, Y. Luan, F. Li, L. Zhang, Z. Tu, Y. Gao, Y. Fu, J. Niu, F.S. Wang, L. Su. Hepatitis B virus infection and immunopathogenesis in a humanized mouse model: induction of human-specific liver fibrosis and M2-like macrophages. PLoS pathogens. 10, e1004032. (2014).

14. M. T. Bility, F. Li, L. Cheng, L. Su. Liver immune-pathogenesis and therapy of human liver tropic virus infection in humanized mouse models. Journal of gastroenterology and hepatology 28 Suppl 1, 120-124. (2013).

15. J. Wang, W. Zhao, L. Cheng, M. Guo, D. Li, X. Li, Y. Tan, S. Ma, S. Li, Y. Yang, L. Chen, S. Wang. CD137-mediated pathogenesis from chronic hepatitis to hepatocellular carcinoma in hepatitis B virus-transgenic mice. J Immunol;185, 7654-7662. (2010).