教育经历
2001-2005 北京大学生命科学学院生物科学专业，学士
2005-2010 北京大学生命科学学院细胞生物学专业，博士
 

工作经历与任职  

2011-2012 美国霍华德休斯医学研究所及北卡罗莱纳大学教堂山分校，博士后
2012-2015 美国霍华德休斯医学研究所及哈佛医学院、波士顿儿童医院，博士后
2015-         武汉大学医学研究院教授、中南医院特聘研究员

研究兴趣

干细胞分化，表观遗传学调控，长非编码RNA，疾病模型，糖尿病

本实验室的长期兴趣是结合发育生物学和遗传学/表观遗传学的基础研究，应用于多能干细胞分化模型来揭示疾病发生的分子机制，关注点是组蛋白修饰、长非编码RNA以及细胞代谢层面的细胞命运决定的分子调控；同时以此获得功能性细胞用于再生医学。研究手段主要包括人多能干细胞建立和维持、定向诱导分化（内胚层和胰腺方向），基因组编辑以及组织工程。目前受国家自然科学基金委重大研究计划培育项目和面上项目、科技部重点研发专项项目支持。

获奖、荣誉、学术兼职  

HMS Epigenetics Initiative Travel Grant (2015);

Juvenile Diabetes Research Foundation (JDRF) Postdoctoral Fellowship (2012-2015);

Beta Cell Biology Consortium (BCBC) Investigator Retreat, Scholarship (2012, 2013);

Science Bulletin 青年编委（2019-）

杂志审稿人： Cell Reports, Stem Cells, Seminars in Cell and Developmental Biology, Stem Cell Research, Tissue Engineering, Stem Cells and Development, Stem Cells Translational Medicine, Experimental Cell Research, Stem Cell Reviews and Reports, Cellular Reprogramming, Journal of Diabetes Research, Molecular and Cellular Biochemistry, Stem Cell International

发表论文概况

已在国际刊物发表论文50多篇，被SCI引用2000余次，主要作者论文单篇最高被引用400余次。

代表性论文（31 out of 50+ ）（# co-first authors；*co-responding authors）

1. Ying Yi, Xianchun Lan, Yinglei Li, Chenchao Yan, Jing Lv, Tianzhe Zhang, Wei Jiang*. Reduced fatty acid synthesis and enhanced oxidation promote human endoderm differentiation by mediating SMAD3 nuclear localization via acetylation. Developmental Cell. (in press)
   

2. Pei Lu#, Jie Yang#, Mao Li#, Shanshan Wen, Tianzhe Zhang, Chenchao Yan, Ran Liu, Yu Xiao, Xinghuan Wang, Wei Jiang*. (2023). A desert lncRNA HIDEN regulates human endoderm differentiation via interacting with IMP1 and stabilizing FZD5 mRNA. Genome Biology. 24(1):92. DOI: 10.1186/s13059-023-02925-w.

3. Chenchao Yan, Yajing Meng, Jie Yang, Jian Chen*, Wei Jiang*. (2023). Translational landscape in human early neural fate determination. Development. 150 (6): dev201177. DOI: 10.1242/dev.201177.

4. Xianchun Lan, Song Ding, Tianzhe Zhang, Ying Yi, Conghui Li, Wenwen Jin, Jian Chen, Kaiwei Liang, Hengbin Wang, Wei Jiang*. (2022). PCGF6 controls human pluripotent stem cell lineage commitment by activating SOX2 expression and repressing WNT signaling pathway. Nature Communications. 13:4601. DOI: 10.1038/s41467-022-32295-z.

5. Li Li#, Zhongjun Wan#, Ruxiang Wang, Yuxin Zhao, Yida Ye, Pengcheng Yang, Yan Qi, Wei Jiang*, Lin Cai*, Donghui Zhang*. (2022). Generation of high-performance human cardiomyocytes and engineered heart tissues from extended pluripotent stem cells. Cell Discovery. DOI: 10.1038/s41421-022-00446-7.

6. Wenwen Jin, Wei Jiang*. (2022). Stepwise differentiation of human pluripotent stem cells into functional pancreatic β cells. Cell Regeneration. 11(1):24. DOI: 10.1186/s13619-022-00125-8.

7. Tianzhe Zhang, Ran Zheng, Mao Li, Chenchao Yan, Xianchun Lan, Bei Tong, Pei Lu, Wei Jiang*. (2022). Active endogenous retroviral elements in human pluripotent stem cells play a role in regulating host gene expression. Nucleic Acids Research. 50(9): 4959-4973. DOI: 10.1093/nar/gkac265.

8. Jing Lv#, Ying Yi#, Yan Qi, Chenchao Yan, Wenwen Jin, Liming Meng, Donghui Zhang*, Wei Jiang*. (2022). Mitochondrial homeostasis regulates definitive endoderm differentiation of human pluripotent stem cells. Cell Death & Discovery. 8:69. DOI: 10.1038/s41420-022-00867-z.

9. Fang Xie#, Lai Jiang#, Ximian Xiao#, Yiwen Lu, Runhui Liu*, Wei Jiang*, Jie Cai*. (2022). Quaternized polysaccharide-based cationic micelles as a macromolecular approach to eradicate multidrug-resistant bacterial infections while mitigating antimicrobial resistance. Small. 2022: e2104885. DOI: 10.1002/smll.202104885.

10. Yan Qi#, Yida Ye#, Ruxiang Wang, Senlin Yu, Yue Zhang, Jing Lv, Wenwen Jin, Shutao Xia, Wei Jiang*, Yifei Li*, Donghui Zhang*. (2022). Mitochondrial dysfunction by TFAM depletion disrupts self-renewal and lineage differentiation of human PSCs by affecting cell proliferation and YAP response. Redox Biology. 50:102248. DOI: 10.1016/j.redox.2022.102248.

11. Lai Jiang, Yiru Shen, Yajing Liu, Lei Zhang*, Wei Jiang*. (2022). Making human pancreatic islet organoids: Progresses on the cell origins, biomaterials and three-dimensional technologies. Theranostics. 12(4):1537-1556. DOI: 10.7150/thno.66670.

12. Song Ding#, Xianchun Lan#, Yajing Meng, Chenchao Yan, Mao Li, Xiang Li*, Jian Chen*, Wei Jiang*. (2021). CHD8 safeguards early neuroectoderm differentiation in human ESCs and protects from apoptosis during neurogenesis. Cell Death & Disease. 12(11):981. DOI: 10.1038/s41419-021-04292-5.

13. Yajing Meng, Tianzhe Zhang, Ran Zheng, Song Ding, Jie Yang, Yingan Jiang*, Wei Jiang*. (2021). Depletion of demethylase KDM6 enhances early neuroectoderm commitment of human PSCs. Frontiers in Cell and Developmental Biology 9:702462. DOI: 10.3389/fcell.2021.702462.

14. Ran Zheng#, Ting Geng#, Dan-Ya Wu#, Tianzhe Zhang, Hainan He, Hai-Ning Du, Donghui Zhang*, Yi-Liang Miao*, Wei Jiang*. (2021). Derivation of feeder-free human extended pluripotent stem cells. Stem Cell Reports 16(7):1686-1696. DOI: 10.1016/j.stemcr.2021.06.001.

15. Pei Lu#, Mao Li#, Donghui Zhang*, Wei Jiang*. (2021). Lnc-ing pluripotency maintenance and early differentiation in human pluripotent stem cells. FASEB Journal 35(4): e21438. DOI: 10.1096/fj.202002278R.

16. Ran Liu#, Kaiyu Qian#, Yu Xiao*, Wei Jiang*. (2021). Generation of two induced pluripotent stem cell lines from blood cells of a prostate cancer patient carrying germline mutation in CHEK2. Stem Cell Research. 53:102299. DOI: 10.1016/j.scr.2021.102299.

17. Jie Yang#, Pei Lu#, Mao Li, Chenchao Yan, Tianzhe Zhang, Wei Jiang*. (2020). GATA6-AS1 Regulates GATA6 Expression to Modulate Human Endoderm Differentiation. Stem Cell Reports 15(3):694-705. DOI: 10.1016/j.stemcr.2020.07.014.

18. Jie Yang, Wei Jiang*. (2020). The Roles of SMAD2/3 in Human Embryonic Stem Cells. Frontiers in Cell and Developmental Biology 8:653. DOI: 10.3389/fcell.2020.00653.

19. Yangyang Yu, Wei Jiang*. (2020). Pluripotent Stem Cell Differentiation as an Emerging Model to Study Human Prostate Development. Stem Cell Research & Therapy 11(1):285. DOI: 10.1186/s13287-020-01801-9.

20. Mengtian Tan, Lai Jiang, Yinglei Li, Wei Jiang*. (2019). Dual inhibition of BMP and WNT signals promotes pancreatic differentiation from human pluripotent stem cells. Stem Cells International 2019:5026793. DOI: 10.1155/2019/5026793.

21. Ting Geng, Donghui Zhang, Wei Jiang*. (2019). Concise Review: Epigenetic Regulation of Transition among Different Pluripotent States. Stem Cells 37(11):1372-1380. DOI: 10.1002/stem.3064.

22. Yinglei Li, Wei Jiang*. (2019). The path and surface marker of SC-β cells. Science Bulletin 64(16), 1122-1124. DOI: 10.1016/j.scib.2019.06.018.

23. Xiaojuan Su#, Mengtian Tan#, Bo Duan, Jie Cai*, Wei Jiang*, Lina Zhang*. (2019). Hierarchical microspheres with macropores fabricated from chitin as 3D cell culture. Journal of Materials Chemistry B 7(34), 5190-5198. DOI: 10.1039/c9tb01046g.

24. Zhang D*, Jiang W*. (2015). From one-cell to tissue: reprogramming, cell differentiation and tissue engineering. Bioscience 65 (5): 468-475. DOI: 10.1093/biosci/biv016.

25. Jiang W*, Liu Y, Liu R, Zhang K, Zhang Y*. (2015). LncRNA DEANR1 facilitates human endoderm differentiation by activating FOXA2 expression. Cell Reports 11(1), 137–148. DOI: 10.1016/j.celrep.2015.03.008.

26. Jiang W*, Zhang D, Bursac N, Zhang Y*. (2013). WNT3 is a biomarker capable of predicting definitive endoderm differentiation potential of hESCs. Stem Cell Reports 1 (1), 46-52. DOI: 10.1016/j.stemcr.2013.03.003.

27. Jiang W, Wang J, Zhang Y*. (2013). Histone H3K27me3 demethylases KDM6A and KDM6B modulate definitive endoderm differentiation from human ESCs by regulating WNT signaling pathway. Cell Research 23(1), 122-130. DOI: 10.1038/cr.2012.119.

28. Jiang W#, Sui X#, Zhang D, Liu M, Ding M, Shi Y*, Deng H*. (2011). CD24: A novel surface marker for PDX1-positive pancreatic progenitors derived from human embryonic stem cells. Stem Cells 29(4):609-617. DOI: 10.1002/stem.608.

29. Zhang D#, Jiang W#, Liu M, Sui X, Yin X, Chen S, Shi Y, Deng H*. (2009). Highly efficient differentiation of human ES cells and iPS cells into mature pancreatic insulin-producing cells. Cell Research 19(4):429-438. DOI: 10.1038/cr.2009.28. 封面文章；被同期专文评述关注；获赛诺菲 - 安万特 Cell Research 2009 年度最佳研究论文奖

30. Jiang W#, Bai Z#, Zhang D, Shi Y, Yong J, Chen S, Ding M, Deng H*. (2008). Differentiation of mouse nuclear transfer embryonic stem cells into functional pancreatic beta cells. Diabetologia 51:1671-1679. DOI: 10.1007/s00125-008-1065-1.

31. Jiang W#, Shi Y#, Zhao D, Chen S, Yong J, Zhang J, Qing T, Sun X, Zhang P, Ding M, Li D*, Deng H*. (2007). In vitro derivation of functional insulin-producing cells from human embryonic stem cells. Cell Research 17:333-344. DOI: 10.1038/cr.2007.28.

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