Guo-Liang Qing, PhD

Research Areas:

Regulation of cancer cell metabolism

Selected Publications:

1.      Xiao D, Ren P, Su H, Yue M, Xiu R, Hu Y, Liu H, Qing G* (2015). Myc promotes glutaminolysis in human neuroblastoma through direct activation of glutaminase 2. Oncotarget, in press.

2.      Gan L, Xiu R, Ren P, Yue M, Su H, Xiao D, Yu J, Jiang H, Liu H, Hu G, Qing G* (2015). Metabolic targeting of oncogene MYC by selective activation of the proton-coupled monocarboxylate family of transporters. Oncogene, in press.

3.      Ren P, Yue M, Xiao D, Xiu R, Gan L, Liu H, Qing G* (2015). ATF4 and N-Myc coordinate glutamine metabolism in MYCN-amplified neuroblastoma cells through ASCT2 activation. The Journal of Pathology 235: 90-100.

4.      Hu Y, Su H, Li X, Guo G, Cheng L, Qin R, Qing G, Liu H (2015). The Notch ligand Jagged2 promotes pancreatic cancer metastasis independent of Notch signaling activation. Molecular Cancer Therapeutics 14: 289-97.

5.       Ye J, Fan J, Venneti S, Wan YW, Pawel BR, Zhang J, Finley LW, Lu C, Lindsten T, Cross J, Qing G, Simon MC, Rabinowitz JD, Thompson CB (2014). Serine catabolism regulates mitochondrial redox control during hypoxia. Cancer Discovery 4: 1406-17.

6.      Qing G, Li B, Liu X, Skuli N, Mayes P, Wide DR, Maris JM, Thompson CB, and Simon MC (2102). ATF4 regulates MYC-mediated cell death upon glutamine deprivation. Cancer Cell 22:631-644.

7.      Qing G, Ma LC, Khorchid A, Swapna GV, Mal TK, Takayama MM, Xia B, Phadtare S, Ke H, Acton T, Montelione GT, Ikura M, Inouye M (2004). Cold-shock induced high-yield protein production in Escherichia coli. Nature Biotechnology 22: 877-82.

8.      Qing G, Skuli N, Mayes P, Paul B, Martinarz D, Maris JM, and Simon MC (2010). Combinatorial regulation of neuroblastoma tumor progression by N-Myc and HIF-1alpha transcription factors. Cancer Research 70:10351-61.

9.      Qing G and Simon MC (2009). Hypoxia inducible factor-2alpha: a critical mediator of aggressive tumor phenotypes. Curr Opin Genet Dev 19: 60-66.

10.  Qing G, Qu Z and Xiao G (2007).  Endoproteolytic processing of C-terminally truncated NF-ҡB2 precursors at promoters containing B site. Proc Natl Acad Sci USA 104: 5324-5329.

11.  Qing G, Yan P, Qu Z, Li H, Rabson AB, Xiao G (2007).  Hsp90 regulates NF-ҡB2 p100 processing involving protection of NF-B inducing kinase from autophagy mediated degradation. Cell Research 16: 895-901.

12.  Qing G, Yan P, Xiao G (2006). Hsp90 inhibition results in autophagy-mediated degradation of the IkappaB kinase. Cell Research 16: 895-901.

13.  Qing G, Qu Z, Xiao G (2005). Stabilization of basally translated NF-ҡB-inducing kinase (NIK) protein functions as a molecular switch of processing of NF-ҡB2 p100. J Biol Chem 280: 40578-82.

14.  Qing G, Xiao G (2005). Essential role of IKK in the constitutive processing of p100 C- terminal truncation mutants. J Biol Chem 280: 9765-8.

15.  Qing G, Qu Z, Xiao G (2005). Regulation of NF-ҡB2 p100 processing by its cis-acting domain. J Biol Chem, 280:18-27.

16.  Vatsyayan J, Qing G, Xiao G, and Hu J (2008). SUMO1 modification of NF-ҡB2 p100 is essential for stimuli-induced p100 phosphorylation and processing. EMBO Report 9: 885-890.

17.  Yan P, Qing G, Qu Z, Wu CC, Rabson A and Xiao G (2007).  Targeting autophagic regulation of NF-ҡB in HTLV-1 transformed cells by geldanamycin: implications for therapeutic interventions. Autophagy 3: 600-603.

18.  Xiao G, Rabson AB, Young W, Qing G and Qu Z (2006). Alternative pathway of NF-ҡB activation: a double-edged sword in health and disease. Cytokine & growth factor reviews 17: 281-293.

19.  Qu Z, Qing G, Rabson A, Xiao G (2004). Tax deregulation of NF-ҡB2 p100 processing involves both beta-TrCP-dependent and -independent mechanisms. J Biol Chem 279: 44563-72.

20.  Zhang Y, Zhang J, Hoeflich KP, Ikura M, Qing G, Inouye M (2003). MazF cleaves cellular mRNAs specifically at ACA to block protein synthesis in Escherichia coli. Molecular Cell 12: 913-23.