Professor, Medical Research Institute
Tel:
Email: jing_zhang@whu.edu.cn
Jing Zhang, PhD
Education
2010-2013 Ph.D Cell Biology and Innate Immunity Wuhan University, P.R. China
2008-2010 M.S Cell Biology and Innate Immunity Wuhan University, P.R. China
2004-2008 B.S Life Science Xiamen University, P.R. China
Professional experience
2019- Professor Medical Research Institute, Wuhan University, P.R. China
2017-2019 Research Assistant Professor, Pathology& Lab Medicine,
Lineberger Comprehensive Cancer Center
The University of North Carolina at Chapel Hill
2013-2017 Postdoc Research Associate Lineberger Comprehensive Cancer Center,
University of North Carolina at Chapel
Honors and awards
2016 DoD Breast Cancer Research Program Breakthrough Fellowship
2015 UCRF Pilot Award
2013 Academic Innovation Award for Graduate Students, Ministry of Education of China
2012 National Scholarship for Graduate Students, Ministry of Education of China
Research Areas
Our research interests involve the study of mechanisms of key signaling transduction pathways and
how alterations in gene expression, post-translational modification or cell metabolism contribute to cancers.
Selected Publications
1. Zhang J*, Wu T*, Simon J, Takada M, Saito R, Fan C, Liu XD, Jonasch E, Xie L, Chen X, Yao X, Teh BT, Tan P, Zheng X, Li M, Lawrence C, Fan J, Geng J, Liu X, Hu L, Wang J, Liao C, Hong K, Zurlo G, Parker JS, Auman JT, Perou CM, Rathmell WK, Kim WY, Kirschner MW, Kaelin WG Jr, Baldwin AS, Zhang Q. VHL substrate transcription factor ZHX2 as an oncogenic driver in clear cell renal cell carcinoma. Science. 2018 Jul 20;361(6399):290-295. doi: 10.1126/science.aap8411. PubMed PMID: 30026228.
Highlighted by Sanchez DJ and Simon MC. Transcriptional control of kidney cancer. Science 2018 Jul 20; 361 (6399): 226-227. DOI: 10.1126/science.aau4385
Commentary: ZHX2 is an oncogenic driver of kidney cancer. Cancer Discovery 2018 Jul 27 DOI: 10.1158/2159-8290.CD-RW2018-125
2. Zhang J#, Zhang Q#. VHL and Hypoxia Signaling: Beyond HIF in Cancer. Biomedicines. 2018 Mar 19;6(1). pii: E35. doi: 10.3390/biomedicines6010035. Review. PubMed PMID: 29562667; PubMed Central PMCID: PMC5874692.
3. Zhang J*, Wang C*, Chen X, Takada M, Fan C, Zheng X, Wen H, Liu Y, Wang CG, Pestell RG, Kaelin WG Jr, Liu XS and Zhang Q (2015). EglN2 Associates with NRF-PGC1α Complex and Controls Mitochondrial Function in Breast Cancer. EMBO J, 2015 Dec 2; 34(23): 2953-70,
4. Zhang J, Zheng X and Zhang Q. EglN2 positively regulates mitochondrial function in breast cancer. Mol Cell Oncol, 2015 Dec 22;3(2):e1120845. doi: 10.1080/23723556.2015.1120845. eCollection 2016 Mar. PubMed PMC4905419.
5. Zhang J, Hu MM, Shu HB, Li S. Death-associated protein kinase 1 is an IRF3/7-interacting protein that is involved in the cellular antiviral immune response. Cell Mol Immunol. 2014 May;11(3):245-52. PubMed PMID: 24531619; PubMed Central PMCID: PMC4085485.
6. Zhang J, Hu MM, Wang YY, Shu HB. TRIM32 protein modulates type I interferon induction and cellular antiviral response by targeting MITA/STING protein for K63-linked ubiquitination. J Biol Chem. 2012 Aug 17;287(34):28646-55. PubMed PMID: 22745133; PubMed Central PMCID: PMC3436586.
7. Ran Y, Zhang J, Liu LL, Pan ZY, Nie Y, Zhang HY, Wang YY. Autoubiquitination of TRIM26 links TBK1 to NEMO in RLR-mediated innate antiviral immune response. J Mol Cell Biol. 2016 Feb;8(1):31-43. PubMed PMID: 26611359.
8. Hu MM, Yang Q, Zhang J, Liu SM, Zhang Y, Lin H, Huang ZF, Wang YY, Zhang XD, Zhong B, Shu HB. TRIM38 inhibits TNFα- and IL-1β-triggered NF-κB activation by mediating lysosome-dependent degradation of TAB2/3. Proc Natl Acad Sci U S A. 2014 Jan 28;111(4):1509-14. PubMed PMID: 24434549; PubMed Central PMCID: PMC3910612.
9. Chen H, Li Y, Zhang J, Ran Y, Wei J, Yang Y, Shu HB. RAVER1 is a coactivator of MDA5-mediated cellular antiviral response. J Mol Cell Biol. 2013 Apr;5(2):111-9. PubMed PMID: 23390309.
10. Lei CQ, Zhong B, Zhang Y, Zhang J, Wang S, Shu HB. Glycogen synthase kinase 3β regulates IRF3 transcription factor-mediated antiviral response via activation of the kinase TBK1. Immunity. 2010 Dec 14;33(6):878-89. PubMed PMID: 21145761.
