CRISPR-Cas: A Tool for Cancer Research and Therapeutics.

In the past decade, the development of a genome-editing technology mediated by CRISPR has made genetic engineering easier than ever, both in vitro and in vivo. CRISPR systems have enabled important advances incancer researchby accelerating the development of study models or as atoolin genetic screening studies, including those aiming to discover and validate therapeutic targets. In this Review, we discuss these applications as well as new potential uses of CRISPR to assist incancerdetection or the development of anticancer therapies.