Cai, C., Geng, A., Wang, M., Yang, L., Yu, Q.C.*, and Zeng, Y.A.*(2019). Amphiregulin mediates the hormonal regulation on Rspondin-1 expression in the mammary gland. Developmental biology.

Abstract

The steroid hormones are instrumental for the growth of mammary epithelial cells. Our previous study indicates that hormones regulate the expression of Rspondin-1 (Rspo1). Yet, the regulatory mechanism remains unknown. In the current study, we identify Amphiregulin (Areg) as a novel upstream regulator of Rspo1 expression mediating the hormonal influence. In response to hormonal signaling, Areg emanating from estrogen receptor (ER)-positive luminal cells, induce the expression of Rspo1 in ER-negative luminal cells. The paracrine action of Areg on Rspo1 expression is dependent on Egfr. Our data reveal a novel Estrogen-Areg-Rspo1 regulatory axis in the mammary gland, providing new evidence for the orchestrated action of systemic hormones and local growth factors.

原文链接：https://www.sciencedirect.com/science/article/abs/pii/S0012160619302325?via%3Dihub