Liang Cheng, PhD

Professor

Medical Research Institute &Frontier Science Center for Immunology and Metabolism, Wuhan University

Tel: 86-27-68750093

Email: liangcheng@whu.edu.cn

Research Areas:

Immunopathogenesis and immunotherapy for virus infection and cancer

Selected Publications: (15 out of 32)

1. L Cheng*, H Yu, J Wrobel, G Li, P Liu, Z Hu, X Xu, L Su. Identification of pathogenic TRAIL-expressing innate immune cells during HIV-1 infection in humanized mice by scRNA-Seq. JCI Insight. 5(11):e135344. (2020). *Co-corresponding author.

2. L Cheng, Q Wang, G Li, J Ma, H Yu, F Yasui, Z Zhang, S Zurawski, G Zurawski, Y Levy, L Su. TLR3 agonist/CD40-targeting vaccination induces T cell response and reduces HIV-1 reservoirs. The Journal of Clinical Investigation. 128(10):4387-4396. (2018).

3. L Cheng*, J Ma, G Li, L Su*. Humanized mice engrafted with human HSC only or HSC and thymus support comparable HIV-1 replication, immunopathology and responses to ART  and immune therapy. Frontiers in Immunology. Apr 19; 9:817. (2018).  *Co-corresponding author.

4. J Zhao^#, L Cheng^#, H Wang, H Yu, B Tu, Q Fu, G Li, Q Wang, Z Liu, L Zhang, L Su, Z Zhang. Infection and depletion of CD4+ group-1 innate lymphoid cells by HIV-1 via type-I interferon pathway. PLoS pathogens. Jan 5; 14(1): e1006819. (2018). ^#Equal contribution

5. L Cheng^#, J Ma^#, J Li^#, D Li, G Li, F Li, Q Zhang, H Yu, F Yasui, C Ye, L-C Tsao, Z  Hu, L Su, L Zhang. Blocking type I interferon signaling enhances T cell recovery and reduces HIV-1 reservoirs. The Journal of Clinical Investigation. 127(1), 269-279. (2017) (Editor’s Pick; Commentary by Steven G. Deeks et al., JCI, 127:103-105. Highlight in Editors'  Choice by Science Translational Medicine.)

6. L Cheng*, H Yu, G Li, F Li, J Ma, J Li, L Chi, L Zhang*, L Su*. Type I Interferons Suppress  Viral Replication but Contribute to T Cell Depletion and Dysfunction during Chronic HIV-1  Infection. JCI Insight. 2(12): e94366. (2017). *Co-corresponding author.

7. L Cheng, Z Zhang, G Li, F Li, L Wang, L Zhang, S Zurawski, G Zurawski, Y Levy, L Su. Human innate responses and adjuvant activity of TLR ligands in vivo in mice reconstituted with a human immune system. Vaccine. Sep 25. pii: S0264-410X (17)31300-2. (2017).

8. Z Zhang^#, L Cheng^#, J Zhao^#, G Li, L Zhang, W Chen, W Nie, N-J Reszka-Blanco, F-S Wang, L Su. Plasmacytoid dendritic cells promote HIV-1-induced group 3 innate lymphoid cell depletion. The Journal of Clinical Investigation. 125, 3692-3703. (2015). ^# Equal contribution. (Editor’s Pick; Commentary by Yang-Xin Fu et al., JCI, 125:3430-31.)

9. L Cheng, F Li, M Bility, C Murphy, and L Su. Modeling hepatitis B virus infection,  immunopathology and therapy in mice. Antiviral research. 121, 1-8. (2015).

10. L Cheng^#, X Du^#, Z Wang, J Ju, M Jia, Q Huang, Q Xing, M Xu, Y Tan, M Liu, P Du, L Su, S Wang. Hyper-IL-15 suppresses metastatic and autochthonous liver cancers by promoting tumor-specific CD8 T cell responses. Journal of Hepatology. 61, 1297-1303. (2014). ^# Equal contribution.

11. L. Cheng, J. Wang, X. Li, Q. Xing, P. Du, L. Su, S. Wang. Interleukin-6 induces Gr-1+CD11b+ myeloid cells to suppress CD8+ T cell-mediated liver injury in mice. PloS one. 6, e1763. (2011).

12. F. Li, L. Cheng, C. M. Murphy, N. J. Reszka-Blanco, Y. Wu, L. Chi, J. Hu, L. Su, Minicircle HBV cccDNA with a Gaussia luciferase reporter for investigating HBV cccDNA biology and developing cccDNA-targeting drugs. Sci Rep. 6, 36483. (2016).

13. M.T. Bility, L. Cheng, Z. Zhang, Y. Luan, F. Li, L. Zhang, Z. Tu, Y. Gao, Y. Fu, J. Niu, F.S. Wang, L. Su. Hepatitis B virus infection and immunopathogenesis in a humanized mouse model: induction of human-specific liver fibrosis and M2-like macrophages. PLoS pathogens. 10, e1004032. (2014).

14. M. T. Bility, F. Li, L. Cheng, L. Su. Liver immune-pathogenesis and therapy of human liver tropic virus infection in humanized mouse models. Journal of gastroenterology and hepatology 28 Suppl 1, 120-124. (2013).

15. J. Wang, W. Zhao, L. Cheng, M. Guo, D. Li, X. Li, Y. Tan, S. Ma, S. Li, Y. Yang, L. Chen, S. Wang. CD137-mediated pathogenesis from chronic hepatitis to hepatocellular carcinoma in hepatitis B virus-transgenic mice. J Immunol;185, 7654-7662. (2010).