|
Professor (Tenured with outstanding score), Principle Investigator Department of Virology, College of Life Sciences Department of Immunology, Medical Research Institute Frontier Science Center for Immunology and Metabolism Wuhan University, Wuhan, China, 430072 Tel: 86-27-68752202 Mobile: 86-18674090967 Fax: 86-27-68752246 Email: zhongbo@whu.edu.cn |
Bo Zhong, PhD
Education
2001.9－2005.6 B.A. in English, Foreign Languages Department, China University of Geosciences, Wuhan, China
2003.2－2005.6 B.S. in Biological Sciences, College of Life Sciences, Wuhan University, Wuhan, China
2005.9－2010.6 Ph.D. in Cell Biology, College of Life Sciences, Wuhan University, Wuhan, China
Employment
2010.07－2013.05 Postdoctoral Fellow, Department of Immunology, The University of Texas, MD Anderson Cancer Center, Houston, TX
2013.03－present Professor, College of Life Sciences, Wuhan University, Wuhan, China
2016.09－present Professor, College of Life Sciences/Medical Research Institute, Wuhan University, Wuhan, China
20118.12－present Professor (Tenured with outstanding score), College of Life Sciences/ Medical Research Institute, Wuhan University, Wuhan, China
Memberships
Chinese Society for Cell Biology
Chinese Society for Immune Cell Biology
Chinese Society for Immunology
American Association of Immunologists
Awards and Honors
2020 Gu Xiaocheng Lecture Award, The Gu Xiaocheng Memorial Fund, USA
2020 AAI Laboratory Travel Grant, American Association of Immunologists, USA
2017 CST-Young Investigator Award, Chinese Society of Cell Biology, China
2016 Zhu Yu-Bi Medical Research Award, Wuhan University
2015 National Natural Science Award, China
2015 One of Ten Excellent Young Faculties of Wuhan University, China
2012 National Excellent Doctoral Dissertation, Ministry of Education, China
2012 Abstract Award, American Association of Immunologists, USA
2011 Odyssey Fellowship, MD Anderson Cancer Center
2010 Invited to the 60th Lindau Nobel Laureates Meeting, Germany
2009 The Ray Wu Prize Fellow, The Ray Wu Memorial Fund, USA (http://www.raywumemorialfund.org/2009winner.php)
Invited Presentations
2021 Annual Meeting of Chinese Society for Biochemistry and Molecular Biology (Kunming, China)
2021 The 3rd Annual Meeting of Chinese Society for Cancer Cell Research (Changchun, China)
2021 Annual Meeting of Chinese Society for Cell Biology (Chongqing, China)
2020 The 8th Meeting of Cellular Basis of Structures and Functions for Signaling Transduction (Tai’an, China)
2020 Annual Meeting of Chinese Society for Biochemistry and Molecular Biology (Shanghai, China)
2020 Annual Meeting of Chinese Society for Cell Biology (Suzhou, China)
2019 Annual Meeting of Chinese Society for Cell Biology (Tianjin, China)
2018 Annual Meeting of Chinese Society for Cell Biology (Nanjing, China)
2017 Annual Meeting of Chinese Society for Cell Biology (Xiamen, China)
2016 The 11th Biennial Meeting of Chinese Biological Investigators Society (Chengdu, China)
2015 Cell Symposium: Cell Death and Immunity (Berkeley, CA, USA)
2014 Annual Meeting of Chinese Society for Cell Biology (Shenzhen, China)
2013 The 14th SCBA International Symposium (Xi’an, China)
Grants
Natural Science Foundation of China (Key Project, 31930040), 01/2020-12/2024, PI, Title: Mechanisms of deubiqtuinating regulation of cGAS and STING, antiviral immunity and autoimmunity
National Key Research and Development Program of China (2018YFE0204500), 08/2019-12/2022, PI, Title: Mechanisms of diseases caused by key internationally emerging viruses
National Key Research and Development Program of China (2018YFC1004601), 08/2018-12/2022, co-PI, Title: Regulatory mechanisms of delivery initiation
The Fundamental Research Funds for the Central Universities (2042020kf0207), 01/2020-12/2021, PI, Title: Infection immunity and inflammatory diseases
Completed:
The Fundamental Research Funds for the Central Universities (2042020kf1059), 01/2020-12/2020, PI, Title: Ubiquitination and deubiquitination-mediated regulation of antiviral immunity and autoimmunity
Natural Science Foundation of China (Regular Project, 31671454), 01/2017-12/2020, PI, Title: Mechanisms of USP18-mediated regulation of virus-triggered type I IFN induction
Natural Science Foundation of China (Excellent Young Scientists, 31622036), 01/2017-12/2019, PI, Title: Antiviral immunity
The Thousand Young Talented Scholars Project, 01/2014-12/2016, PI, Title: Antiviral immunity and inflammatory diseases
Natural Science Foundation of China (Regular Project, 31371427), 01/2014-12/2017, PI, Title: Mechanisms of USP25-mediated regulation of TLR signaling
Funding for National Excellent Doctoral Dissertation (201427), 01/2014-12/2017, PI, Title: Regulation of tumorigenesis of non-small cell lung cancer by cytokines and chemokines
Editorial Board
Editorial Member, Journal of Cell Biology (02/2022-01/2024)
Associate Editor, Cell Insight (Since 05/2021)
Associate Editor, Frontier in Microbiology (Since 05/2021)
Editor, Virologica Sinica (Since 01/2017)
Journal Reviews
Nature Immunology, Cell Host Microbe, Advanced Science, Journal of Clinical Investigation, Cell Reports, PNAS, Cancer Letters, Journal of Immunology, Journal of Biological Chemistry, Scientific Reports, Frontier in Cell and Developmental Biology, Frontier in Immunology etc.
Committees and Services
Member, Education Committee, Medical Research Institute (2018-present)
Member, Academic Degrees Committee, Medical Research Institute (2018-present)
Director, Department of Immunology, Medical Research Institute (2017-present)
Teaching
09/2020-01/2021, Immunology, College of Life Sciences
10/2020, Molecular Biology of the Cell, Medical research Institute
09/2019-01/2020, Immunology, College of Life Sciences
10/2019, Molecular Biology of the Cell, Medical research Institute
09/2017-01/2018, Immunology, College of Life Sciences
09/2016-01/2017, Immunology, College of Life Sciences
Mentor Experiences
Junior faculty mentorship
Dr. Jing Zhang, Professor, Medical Research Institute, 05/2019-present
Dr. Bin Wu, Professor, Medical Research Institute, 03/2021-present
Ph.D. student mentorship
Dr. Yin Zhao, 09/2013-06/2018, (Postdoctoral fellow, Sun Yat-Sen University)
Dr. Yujie-Ren, 09/2013-06/2018, (Postdoctoral fellow, Wuhan Institute of Virology)
Dr. Tianzi Liuyu, 09/2014-06/2019, (Administrative Staff, Medical Research Institute)
Dr. Man Zhang, 09/2014-06/2019, (Senior Scientists, Hengrui Pharmaceuticals)
Dr. Zeng Cai, 09/2014-06/2020, (Research Scientists, Wuhan University)
Dr. Qiang Zhang, 09/2015-06/2020, (Postdoctoral fellow, Sun Yat-Sen University)
Dr. Meng-Xin Zhang, 09/2015-06/2020, (Postdoctoral fellow, Military Medical Institute)
Dr. Xiao-Meng Wang, 09/2016-06/2020, (Scientists, Yuanda Pharmaceuticals)
Dr. Zhi-Dong Zhang, 09/2016-06/2021, (Postdoctoral fellow, Wuhan University)
Dr. Tian-Chen Xiong, 09/2016-06/2021, (Postdoctoral fellow, Army Medical University)
Dr. Wei Yang, 09/2017-06/2022, (Research Associate, Yunnan University)
Dr. Peng Wang, 09/2017-06/2022, (Postdoctoral fellow, Wuhan University)
Dr. Ran An, 09/2017-09/2022
Currently, there are 10 Ph.D. candidates in my lab.
Graduate student mentorship
Mr. Jie Jin, 09/2013-06/2016, (Ph.D. student, Tsinghua University)
Mr. He Sun, 09/2014-06/2016, (Researcher, Qilu Pharmaceuticals)
Ms. Ying-Ying Jing, 09/2015-06/2018
Ms. Li-Ya Ye, 09/2016-06/2019, (Marketing, Procter & Gamble)
Mr. Hao Guo, 09/2019-06/2022
Ms. Hu Gan, 09/2020-06/2022, (PhD candidate, Wuhan University)
Undergraduate student mentorship
About 20 students.
Publications (*corresponding authorship)
1. Xiong TC#, Wei MC#, Li FX#, Shi M, Gan H, Tang Z, Dong HP, Liuyu T, Gao P, Zhong B*, Zhang ZD*, Lin D*. The E3 ubiquitin ligase ARIH1 promotes antiviral immunity and autoimmunity by inducing mono-ISGylation and oligomerization of cGAS. Nat Commun, Accepted.
2. An R, Wang P, Guo H, Liuyu T, Zhong B*, Zhang ZD*. USP2 promotes experimental colitis and bacterial infections by inhibiting the proliferation of myeloid cells and remodeling the extracellular matrix network. Cell Insight, 2022, 1(4): 100047. doi: 10.1016/j.cellin.2022.100047.
3. Zhang ZD, Li HX, Gan H, Tang Z, Guo YY, Yao SQ, Liuyu T, Zhong B*, Lin D*. RNF115 inhibits the post-ER trafficking of TLRs and TLRs-mediated immune responses by catalyzing K11-linked ubiquitination of RAB1A and RAB13. Adv Sci, 2022, 9(16): 2105391. doi: 10.1002/advs.202105391.
4. Yang W#, Dong HP#, Wang P#, Xu ZG, Xian J, Chen J, Wu H, Lou Y, Lin D*, Zhong B*. IL-36g and IL-36Ra reciprocally regulate colon tumorigenesis by modulating the cell-matrix adhesion network and Wnt signaling. Adv Sci, 2022, 9(10): 2103035. doi: 10.1002/advs.202103035.
5. Yang W#, Dong HP#, Wang P#, Xu ZG, Xian J, Chen J, Wu H, Lou Y, Lin D*, Zhong B*. IL-36g and IL-36Ra reciprocally regulate colon tumorigenesis by modulating the cell-matrix adhesion network and Wnt signaling. Adv Sci, 2022, 9: 2103035. doi: 10.1002/advs.202103035.
6. Zhang ZD, Zhong B*. Regulation and function of the cGAS-MITA/STING axis in health and disease. Cell Insight, 2022, 1(1): 100001. doi: 10.1016/j.cellin.2021.100001.
7. Mo X, Liu Q, Gao L, Xie C, Wei X, Pang P, Tian Q, Gao Y, Zhang Y, Wang Y, Xiong T, Zhong B, Li D, Yao J*. The industrial solvent 1,4-Dioxane causes hyperalgesia by targeting capsaicin receptor TRPV1. BMC Biology, 2022, 20(1): 10. doi: 10.1186/s12915-021-01211-0.
8. Wang P#, Yang W#, Guo H, Dong HP, Guo YY, Gan H, Wang Z, Cheng Y, Deng Y, Xie S, Yang X, Lin D*, Zhong B*. IL-36g and IL-36Ra reciprocally regulate NSCLC progression by modulating GSH homeostasis and oxidative stress-induced cell death. Adv Sci, 2021, 8(19): 2101501. doi: 10.1002/advs.202101501.
9. Wang Z, Chen J, Gao C, Xiao S, Wang XW, Tang SB, Li QL, Zhong B, Song ZY, Shu HB, Li LY, Wu M*. Epigenetic Dysregulation Induces Translocation of Histone H3 into Cytoplasm. Adv Sci, 2021, 8: 2100779, doi: 10.1002/advs.202100779.
10. Tang JL, Yang Q, Xu CH, Zhao H, Liu YL, Liu CY, Zhou Y, Gai DW, Pei RJ, Wang Y, Hu X, Zhong B, Wang YY, Chen XW*, Chen JZ*. Histone deacetylase 3 promotes innate antiviral immunity through deacetylation of TBK1. Protein Cell. 2021, 12(4): 261-278.
11. Wu X, Wang Y, Huang R, Gai Q, Liu H, Shi M, Zhang X, Zuo Y, Chen L, Zhao Q, Shi Y, Wang F, Yan X, Lu H, Xu S, Yao X, Chen L, Zhang X, Tian Y, Yang Z, Zhong B, Dong C, Wang Y*, Bian XW*, Liu X*. SOSTDC1-producing follicular helper T cells promote regulatory follicular T cell differentiation. Science, 2020, 369(6506):984-988. doi: 10.1126/science.aba6652.
12. Zhang M#, Yang W#, Wang P, Deng Y, Dong YT, Liu FF, Huang R, Zhang P, Duan YQ, Liu XD, Lin D*, Chu Q*, Zhong B*. CCL7 recruits cDC1 to promote antitumor immunity and facilitate checkpoint immunotherapy to non-small cell lung cancer. Nat Commun, 2020, 11: 6119. Nov 30, doi: 10.1038/s41467-020-19973-6.
13. Zhang ZD#, Xiong TC#, Yao SQ, Wei MC, Chen M, Lin D, Zhong B*. RNF115 plays dual roles in innate antiviral responses by catalyzing distinct ubiquitination of MAVS and MITA. Nat Commun, 2020, 11: 5536. Nov 2, doi: 10.1038/s41467-020-19318-3.
14. Wang XM, Yang C, Zhao Y, Xu Z, Yang W, Wang P, Lin D, Xiong B, Fang J, Dong C, Zhong B*. The deubiquitinase USP25 supports colonic inflammation and bacterial infection and promotes colorectal cancer. Nat Cancer, 2020, 1: 811-825. July 6, doi: 10.1038/s43018-020-0089-4.
15. Zhang Q, Tang Z, An R, Ye L, Zhong B*. USP29 maintains the stability of cGAS and promotes cellular antiviral responses and autoimmunity. Cell Res, 2020, 30, 914-927. May 26, doi: 10.1038/s41422-020-0341-6.
16. Lin D*, Zhang M, Guo H, Deng Y, Zhong B, Liao F*, Xu ZG*. Dispensable role of CCL28 in Kras-mutated non-small cell lung cancer mouse models. Acta Biochim Biophys Sin. 2020, 52(6): 1-4. doi: 10.1093/abbs/gmaa032.
17. Cai Z, Zhang MX, Tang Z, Zhang Q, Ye J, Xiong TC, Zhang ZD, Zhong B*. USP22 promotes IRF3 nuclear translocation and antiviral responses by deubiquitinating the importin protein KPNA2. J Exp. Med., 2020, 217, 5: e20191174.
18. Chen L, Liu W, Zhang Q, Xu K, Ye G, Wu W, Sun Z, Liu F, Wu K, Zhong B, Mei Y, Zhang W, Chen Y*, Li Y*, Shi M*, Lan K*, Liu Y*. RNA based mNGS approach identifies a novel human coronavirus from two individual pneumonia cases in 2019 Wuhan outbreak. Emerg Microbes Infect., 2020 Feb 5; 9(1): 313-319.
19. Li SZ*, Shu QP, Song Y, Zhang HH, Liu Y, Jin BX, Liuyu TZ, Li C, Huang XC, Du RL, Song W*, Zhong B*, Zhang XD*. Phosphorylation of MAVS/VISA by Nemo-like kinase (NLK) for degradation regulates the antiviral innate immune response. Nat Commun, 2019, 10(1): 3233.
20. Liu X*, Wang Y, Lu H, Li J, Yan X, Xiao M, Hao J, Alekseev A, Khong H, Chen T, Huang R, Wu J, Zhao Q, Wu Q, Xu S, Wang X, Jin W, Yu S, Wang Y, Wei L, Wang A, Zhong B, Ni L, Liu X, Nurieva R, Ye L, Tian Q, Bian XW*, Dong C*. Genome-wide analysis identifies NR4A1 as a key mediator of T cell dysfunction. Nature, 2019, 567(7749): 525-529.
21. Tian Q, Hu J, Xie C, Mei K, Pham C, Mo X, Hepp R, Soares S, Nothias F, Wang Y, Liu Q, Cai F, Zhong B, Li D, Yao J. Recovery from tachyphylaxis of TRPV1 coincides with recycling to the surface membrane. Proc Natl Acad Sci U S A. 2019116(11): 5170-5175.
22. Ye L#, Zhang Q#, Liuyu T, Xu Z, Zhang MX, Luo MH, Zeng WB, Zhu Q, Lin D*, Zhong B*. USP49 negatively regulates cellular antiviral responses via deconjugating K63-linked ubiquitination of MITA. Plos Pathog, 2019, 15(4): e1007680.
23. Zhang MX, Cai Z, Zhang M, Wang XM, Wang Y, Zhao F, Zhou J, Luo MH, Zhu Q, Xu Z, Zeng WB*, Zhong B*, Lin D*. USP20 promotes cellular antiviral responses via deconjugating K48-linked ubiquitination of MITA. J Immunol, 2019, 202(8):2397-2406.
24. Liuyu T, Yu K, Ye L, Zhang Z, Zhang M, Ren Y, Cai Z, Zhu Q, Lin D, Zhong B*, Induction of OTUD4 by viral infection promotes antiviral responses through deubiquitinating and stabilizing MAVS. Cell Res, 2019, 29(1):67-79.
25. Lei CQ, Wu X, Zhong X, Jiang L, Zhong B, Shu HB*. USP19 Inhibits TNF-α– and IL-1β–Triggered NF-κB Activation by Deubiquitinating TAK1. J Immunol., 2019, 203(1): 259-268.
26. Zhao Y, Wang XM, Wang Q, Deng Y, Li K, Zhang M, Zhang Q, Zhou J, Wang HY, Bai P, Ren Y, Zhang N, Li W, Cheng Y, Xiao W, Du HN, Cheng X, Yin L, Fu X, Lin D, Zhou Q, Zhong B*, USP2a supports metastasis by tuning TGF-b signaling. Cell Rep, 2018, 22(9):2442-2454.
27. Li Q, Li L, Tong Y, Liu Y, Mou J, Wang X, Wang X, Gong Y, Zhao Y, Liu Y, Zhong B, Dai L, Wei Y, Zhang H*, Hu H*. TRIM29 negatively controls antiviral immune response through targeting STING for degradation. Cell Discov. 2018, 4:13.
28. Li K, Zhong B*, Regulation of cellular antiviral signaling by modifications of ubiquitin and ubiquitin-like molecules. Immune Network. 2018, 18(1):e4. (Invited review)
29. Lu B#, Ren Y#, Sun X#, Han C, Wang H, Chen Y, Peng Q, Cheng Y, Cheng X, Zhu Q, Li W, Li HL, Du HN, Zhong B*, Huang Z*. Induction of INKIT by viral infection negatively regulates antiviral responses through inhibiting phosphorylation of p65 and IRF3. Cell Host Microbe, 2017, 22(1):86-98.e4. (Cover story)
30. Sun H#, Zhang Q#, Jing YY, Zhang M, Wang HY, Cai Z, Liuyu T, Zhang ZD, Xiong TC, Wu Y, Zhu QY, Yao J, Shu HB, Lin D, Zhong B*. USP13 negatively regulates antiviral responses by deubiquitinating STING. Nat Commun. 2017, May 23; 8:15534. 10.1038/NCOMMS15534.
31. Wang X, Ni L, Chang D, Lu H, Jiang Y, Kim BS, Wang A, Liu X, Zhong B, Yang X, Dong C*. Cyclic AMP-Responsive Element-Binding Protein (CREB) is Critical in Autoimmunity by Promoting Th17 but Inhibiting Treg Cell Differentiation. EBioMedicine. 2017, 25:165-174. doi: 10.1016/j.ebiom.2017.10.010.
32. Zhu Y, Gu L, Li Y, Lin X, Shen H, Cui K, Chen L, Zhou F, Zhao Q, Zhang J, Zhong B, Prochownik E, Li Y*. miR-148a inhibits colitis and colitis-associated tumorigenesis in mice. Cell Death Differ. 2017, 24(12):2199-2209.
33. Yang Q, Liu TT, Lin H, Zhang M, Wei J, Luo WW, Hu YH, Zhong B, Hu MM*, Shu HB*. TRIM32-TAX1BP1-dependent selective autophagic degradation of TRIF negatively regulates TLR3/4-mediated innate immune responses. PLoS Pathog. 2017, 13(9):e1006600.
34. Cheng L, Ren Y, Lin D, Peng S, Zhong B, Ma Z*. The Anti-Inflammatory Properties of Citrus wilsonii Tanaka Extract in LPS-Induced RAW 264.7 and Primary Mouse Bone Marrow-Derived Dendritic Cells. Molecules. 2017, 22(7). pii: E1213
35. Qiu Y, Xu Y, Zhang Y, Zhou H, Deng YQ, Li XF, Miao M, Zhang Q, Zhong B, Hu Y, Zhang FC, Wu L, Qin CF*, Zhou X*. Human Virus-Derived Small RNAs Can Confer Antiviral Immunity in Mammals. Immunity. 2017, 46(6):992-1004.e5.
36. Peng Q, Lan X, Wang C, Ren Y, Yue N, Wang J, Zhong B, Zhu Q*. Kobuvirus VP3 protein restricts the IFN-β-triggered signaling pathway by inhibiting STAT2-IRF9 and STAT2-STAT2 complex formation. Virology. 2017 Apr 22; 507:161-169.
37. Wang A, Ding X, Demarque M, Liu X, Pan D, Xin H, Zhong B, Wang X, Dejean A, Jin W, Dong C. Ubc9 Is Required for Positive Selection and Late-Stage Maturation of Thymocytes. J Immunol. 2017 May 1; 198(9):3461-3470.
38. Gao SF, Zhong B, Lin D*. Regulation of T helper cell differentiation by E3 ubiquitin ligases and deubiquitinating enzymes. Int Immunopharmacol. 2017, 42:150-156.
39. Wang J, Lei CQ, Ji Y, Zhou H, Ren Y, Peng Q, Zeng Y, Jia Y, Ge J, Zhong B, Li Y, Wei J, Shu HB, Zhu Q*. Duck Tembusu Virus Nonstructural Protein 1 Antagonizes IFN-β Signaling Pathways by Targeting VISA. J Immunol. 2016, 197(12):4704-4713.
40. Zhang M#, Zhang MX#, Zhang Q, Zhu GF, Yuan L, Zhang DE, Zhu QY, Yao J, Shu HB, Zhong B*. USP18 recruits USP20 to promote innate antiviral response through deubiquitinating STING/MITA. Cell Res. 2016, 26(12): 1302-1319.
41. Ren Y, Zhao Y, Lin D, Xu X, Zhu Q, Yao J, Shu HB, Zhong B*. The type I interferon-IRF7 axis mediates transcriptional expression of Usp25 gene. J Biol Chem. 2016, 291(25): 13206-13215.
42. Lin D, Zhang M, Zhang MX, Ren YJ, Jin J, Zhao Q, Pan Z, Wu M, Shu HB, Dong C, Zhong B*. Induction of USP25 by viral infection promotes innate antiviral responses by mediating the stabilization of TRAF3 and TRAF6. Proc Natl Acad Sci U S A. 2015 112(36):11324-329.
43. Lin D, Zhong B*. Regulation of cellular innate antiviral signaling by ubiquitin modification. Acta Biochim Biophys Sin. 2015 47(3):149-155. (Invited Review)
44. Luo WW, Li S, Li C, Lian H, Yang Q, Zhong B, Shu HB*. iRhom2 is essential for innate immunity to DNA viruses by mediating trafficking and stability of the adaptor STING. Nat Immunol. 2016, 17(9): 1057-66.
45. Liu TT, Yang Q, Li M, Zhong B, Ran Y, Liu LL, Yang Y, Wang YY, Shu HB*. LSm14A Plays a Critical Role in Antiviral Immune Responses by Regulating MITA Level in a Cell-Specific Manner. J Immunol. 2016 196(12):5101-11.
46. An T, Li S, Pan W, Tien P, Zhong B, Shu HB, Wu S*. DYRK2 Negatively Regulates Type I Interferon Induction by Promoting TBK1 Degradation via Ser527 Phosphorylation. PLoS Pathog. 2015 11(9): e1005179.
47. Wei J, Lian H, Zhong B, Shu HB*. Parafibromin is a component of IFNγ-triggered signaling pathways that facilitates JAK1/2-mediated tyrosine phosphorylation of STAT1. J Immunol. 2015 195(6):2870-8.
48. Deng T, Lin D, Zhang M, Zhao Q, Li W, Zhong B, Deng Y, Fu X*. Differential expression of bone morphogenetic protein 5 in human lung squamous cell carcinoma and adenocarcinoma. Acta Biochim Biophys Sin. 2015 47(7):557-63.
49. Liu X, Chen X, Zhong B, Wang A, Wang X, Chu F, Nurieva RI, Yan X, Chen P, van der Flier LG, Nakatsukasa H, Neelapu SS, Chen W, Clevers H, Tian Q, Qi H, Wei L, Dong C*. Transcription factor achaete-scute homologue 2 initiates follicular T-helper-cell development. Nature. 2014, 507(7493):513-8.
50. Luo WW, Lian H, Zhong B, Shu HB, Li S*. Krüppel-like factor 4 negatively regulates cellular antiviral immune response. Cell Mol Immunol. 2016, 13(1):65-72.
51. Zhou Q, Lin H, Wang S, Wang S, Ran Y, Liu Y, Ye W, Xiong X, Zhong B, Shu HB*, Wang YY*. The ER-associated protein ZDHHC1 is a positive regulator of DNA virus-triggered, MITA/STING-dependent innate immune signaling. Cell Host Microbe. 2014, 16(4):450-61.
52. Qin Y, Zhou MT, Hu MM, Hu YH, Zhang J, Guo L, Zhong B, Shu HB*. RNF26 temporally regulates virus-triggered type I interferon induction by two distinct mechanisms. PLoS Pathog. 2014, 10(9):e1004358.
53. Lei CQ, Zhang Y, Li M, Jiang LQ, Zhong B, Kim YH, Shu HB*. ECSIT Bridges RIG-I-Like Receptors to VISA in Signaling Events of Innate Antiviral Responses. J Innate Immun. 2015, 7(2):153-64.
54. Zhang Y, Lei CQ, Hu YH, Xia T, Li M, Zhong B, Shu HB*. Krüppel-like factor 6 is a co-activator of NF-κB that mediates p65-dependent transcription of selected downstream genes. J Biol Chem. 2014, 289(18):12876-85.
55. Hu MM, Yang Q, Zhang J, Liu SM, Zhang Y, Lin H, Huang ZF, Wang YY, Zhang XD, Zhong B, Shu HB*. TRIM38 inhibits TNFα- and IL-1β-triggered NF-κB activation by mediating lysosome-dependent degradation of TAB2/3. Proc Natl Acad Sci U S A. 2014, 111(4):1509-14.
56. Lei CQ, Zhang Y, Xia T, Jiang LQ, Zhong B, Shu HB*. FoxO1 negatively regulates cellular antiviral response by promoting degradation of IRF3. (2013). J Biol Chem. 288, 12596-604.
57. Zhong B, Liu XK, Wang XH, Liu XD, Li HX, Darnay BR, Lin X, Sun SC and Dong C*. Ubiquitin-specific protease 25 regulates TLR4-dependent innate immune response through deubiquitination of TRAF3. (2013). Sci Signal. 6, ra35.
58. Liu XK#, Li HX#, Zhong B#, Blonska M, Gorjestani S, Yan M, Tian Q, Zhang DE, Lin X* and Dong C*. USP18 inhibits NF-κB and NFAT activation during Th17 differentiation by deubiquitinating the TAK1-TAB1 complex. (2013). J Exp Med. 210, 1575-90. (#Co-first authors)
59. Zhong B, Liu XK, Wang XH, Chang SH, Liu XD, Wang AB, Reynolds JM, and Dong C*. Negative regulation of IL-17-mediated signaling and inflammation by the ubiquitin-specific protease USP25. (2012). Nat Immunol. 13, 1110-17.
60. Liu XD, Yan X, Zhong B, Nurieva RI, Wang A, Wang X, Martin-Orozco N, Wang Y, Chang SH, Esplugues E, Flavell RA, Tian Q, Dong C*. Bcl6 expression specifies the T follicular helper cell program in vivo. (2012). J Exp Med. 209:1841-52.
61. Xu T#, Wang X#, Zhong B, Nurieva RI, Ding S, Dong C*. Ursolic acid suppresses interleukin-17 (IL-17) production by selectively antagonizing the function of RORgamma t protein. (2011). J Biol Chem. 286, 22707-10.
62. Lei CQ, Zhong B, Zhang Y, Zhang J, Wang S and Shu HB*. Glycogen synthase kinase 3β regulates IRF3 transcription factor-mediated antiviral response via activation of the kinase TBK1. (2010). Immunity. 33, 878-89.
63. Zhong B, Zhang Y, Tan B, Liu TT, Wang YY and Shu HB*. The E3 ubiquitin ligase RNF5 targets virus-induced signaling adaptor for ubiquitination and degradation. (2010). J Immunol. 184, 6249-6255.
64. Zhong B, Wang YY and Shu HB*. Regulation of virus-triggered type I interferon signaling by cellular and viral proteins. (2010). Frontier in Biology 5, 12-31.
65. Zhong B, Zhang L, Lei CQ, Li Y., Mao AP, Yang Y, Wang YY, Zhang XL and Shu HB*. The ubiquitin ligase RNF5 regulates antiviral responses by mediating degradation of the adaptor protein MITA. (2009). Immunity 30, 397-407.
66. Zhong B, Yang Y, Li S, Wang YY, Li Y, Diao FC, Lei CQ, He X, Zhang L, Tien, P and Shu HB*. The adapter protein MITA links virus-sensing receptors to IRF3 transcription factor activation. (2008). Immunity 29, 538–550.
67. Zhong B, Tien P and Shu HB*. Innate immune responses: crosstalk of signaling and regulation of gene transcription. (2006). Virology 352, 14-21.
68. Wang YY, Liu LJ, Zhong B, Liu TT, Li Y, Yang Y, Ran Y, Li S, Tien P and Shu HB*. WDR5 is essential for assembly of the VISA-associated signaling complex and virus-triggered IRF3 and NF-kB activation. (2010). Proc Natl Acad Sci U S A. 107, 815-820.
69. Mao AP, Li S, Zhong B, Li Y, Yan J, Li Q and Shu HB*. Virus-triggered ubiquitination of TRAF3 by cIAP1/2 at the mitochondria is essential for induction of IFN-b and cellular antiviral response. (2010). J Biol Chem. 285, 9470-9476.
70. Chen R, Zhang L, Zhong B, Tan B, Liu Y and Shu HB*. Ubiquitin-specific protease 17 is involved in virus-triggered type I interferon signaling. (2010). Cell Res. 20: 802-11.
71. Li S, Zheng H, Mao AP, Zhong B, Li Y, Liu Y, Gao Y, Ran Y, Tien P and Shu HB*. Regulation of virus-triggered signaling by OTUB1- and OTUB2-mediated deubiquitination of TRAF3 and TRAF6. (2010). J Biol Chem. 285, 4291-4297.
72. Li Y, Li C, Xue P, Zhong B, Mao AP, Ran Y, Chen H, Wang YY, Yang FQ and Shu HB. ISG56 is a negative regulator of virus-triggered signaling and cellular antiviral response. (2009). Proc Natl Acad Sci U S A. 106, 7945-50.
73. Daio FC, Li S, Tian Y, Zhang M, Xu LG, Zhang Y, Wang RP, Zhai Z, Zhong B, Tien P and Shu HB*. Negative regulation of MDA5- but not RIG-I-mediated innate antiviral signaling by the dihydroxyacetone kinase. (2007). Proc Natl Acad Sci U S A. 104, 11706-11711.
74. Tian Y#, Zhang Y#, Zhong B, Wang YY, Diao FC, Wang RP, Zhang M, Chen DY, Zhai Z and Shu HB*. RBCK1 negatively regulates tumor necrosis factor- and interleukin-1-triggered NF-kappaB activation by targeting TAB2/3 for degradation. (2007). J Biol Chem. 282, 16776-11782. (#Co-first authors).
75. 张煜，钟波，杨艳，舒红兵*. TLRs与RLRs介导的细胞抗病毒反应信号转导及其调节机制. (2009). 细胞生物学杂志 31, 453-468.
76. 钟波，舒红兵*. 天然免疫模式识别受体与树突状细胞的发现和意义——2011年诺贝尔生理学或医学奖成果和相关研究. 生命科学 (2011). 23, 1147-1161.
