Professor

  Frontier Science Center for Immunology and Metabolism

  Medical Research Institute

  Tel: 86-27-68750121

  Email: mmhu@whu.edu.cn

Research Areas:

Mechanism of antiviral innate immune responses and antitumor immune response

Selected Publications:

1．Yang, Y.L.^#, Cao, L.B.^#, He, W.R.^#, Zhong, L., Guo, Y., Yang, Q., Shu, H.B., and Hu, M.M.* (2022). Endocytosis triggers V-ATPase-SYK-mediated priming of cGAS activation and innate immune response. PNAS 119, e2207280119.

2．Cao, L.B., Ruan Z.L., Yang Y.L., Zhang N.C., Gao, C., Cai, C.G., Zhang J., Hu, M.M.,* and Shu H.B.* (2023). Estrogen receptor a-mediated signaling inhibits type I interferon response to promote breast cancer. J Mol Cell B (In press)

3．Guo, Y., Zhang, X.N., Su, S., Ruan, Z.L., Hu, M.M.*, and Shu, H.B.* (2023). beta-adrenoreceptor-triggered PKA activation negatively regulates the innate antiviral response. Cell Mol Immunol 20, 175–188.

4．Su, S.#, Hua, D.#, Li, J.P.#, Zhang, X.N., Bai, L., Cao, L.B., Guo, Y., Zhang, M., Dong, J.Z., Liang, X.W., Lan, K., Hu, M.M.*, and Shu, H.B.* (2022). Modulation of innate immune response to viruses including SARS-CoV-2 by progesterone. Signal Transduct Target Ther 7(1):137

5．He W.R., Cao L.B., Yang Y.L., Hua D., Hu M.M.* and Shu H.B.* (2021). VRK2 is involved in innate antiviral response by promoting mitostress-induced mtDNA release. Cell Mol Immunol 18(5):1186-1196.

6．Hu M.M.* and Shu H.B.*(2020). Innate Immune Response to Cytoplasmic DNA: Mechanisms and Diseases. Ann Rev Immunol 38:78-89.

7．Hu M.M.*, He W.R., Gao P., Yang Q., He K., Cao L.B., Li S., Feng Y.Q. and Shu H.B.* (2019). Virus-induced accumulation of intracellular bile acids activates the TGR5-b-arrestin-SRC axis to enable innate antiviral immunity. Cell Research 29, 193-205

8．Hu M.M.* and Shu H.B.* (2018). Cytoplasmic mechanisms of recognition and defense of microbial nucleic acids. Ann Rev Cell Dev Bi 34, 357-379

9．Yang, Q., Liu, T.T., Lin, H., Zhang, M., Wei, J., Luo, W.W., Hu, Y.H., Zhong, B., Hu, M.M.*, and Shu, H.B.* (2017). TRIM32-TAX1BP1-dependent selective autophagic degradation of TRIF negatively regulates TLR3/4-mediated innate immune responses. PLoS Pathog 13(9):e1006600.

10．Hu, M.M., Liao, C.Y., Yang, Q., Xie, X.Q., and Shu. H.B.* (2017). Innate immunity to RNA virus is regulated by temporal and reversible sumoylation of RIG-I and MDA5. J Exp Med 214(4):973-989.

11．Hu, M.M. and Shu H.B. (2017). Multifaceted roles of TRIM38 in innate immune and inflammatory responses. Cell Mol Immunol 14(4):331-338.

12．Hu, M.M., Yang, Q., Xie, X.Q., Liao, C.Y., Lin, H., Liu, T.T., and Shu, H.B. (2016). Sumoylation promotes the stability of the DNA sensor cGAS and the adaptor STING to regulate the kinetics of response to DNA virus. Immunity 45, 555-569.

13．Hu, M.M., Xie, X.Q., Yang, Q., Liao, C.Y., Ye, W., Lin, H., and Shu, H.B.* (2015). TRIM38 Negatively Regulates TLR3/4-Mediated Innate Immune and Inflammatory Responses by Two Sequential and Distinct Mechanisms. J Immunol 195, 4415-4425.

14．Hu, M.M., Yang, Q., Zhang, J., Liu, S.M., Zhang, Y., Lin, H., Huang, Z.F., Wang, Y.Y., Zhang, X.D., Zhong, B., and Shu, H.B. (2014). TRIM38 inhibits TNFalpha- and IL-1beta-triggered NF-kappaB activation by mediating lysosome-dependent degradation of TAB2/3. PNAS 111, 1509-1514.